Standard test systems include Phosphate Buffered Saline (PBS) pH 7.4, Simulated Gastric Fluid (SGF), and Simulated Intestinal Fluid (SIF).
Additional test systems available upon request.
Stability determined by measuring percent remaining of test compound at multiple time points during incubation in selected media.
Test Compound Concentration
Percent Organic Solvent in Incubation
Incubation Time (PBS)
0, 2, 4, 6, 8, 24, 48, 72 hours
Incubation Time (SGF, SIF)
0, 15, 30, 60, and 90 minutes
7.4 (PBS), 1.2 (SGF), 5.0 (fed-state SIF), 6.5 (fasted-state SIF)
Verapamil and Tamoxifen
LC-MS (LC-MS/MS if necessary)
Number of Repeats
Half-life of test compound.
Test Compound Requirement:
1-2 mg dry powder or 100-200 µL of 10 mM DMSO stock solution.