Stability in Plasma
Blood plasma from desired species.
Stability determined by measuring percent remaining of test compound at multiple time points during incubation in plasma.
Test Compound Concentration
Percent Organic Solvent in Incubation
0, 15, 30, 60, and 90 minutes
Propantheline and/or Enalapril
LC-MS (LC-MS/MS if necessary)
Number of Repeats
Half-life of test compound.
Test Compound Requirement:
1-2 mg dry powder or 100-200 µL of 10 mM DMSO stock solution.